Microbial profiling

IBD includes two different pathologies, Ulcerative colitis (UC) and Crohn’s disease (CD). We planned to compare patients in remission with a similar number of healthy individuals, generally from the same family (30 for each disease). The clinical part of the UC study has now been completed. The individuals have been enrolled into the study, they were clinically examined and their samples (blood and stools) obtained and analyzed. We anticipate that the CD study will reach the same stage before the end of the year, as almost 90% of the individuals have been enrolled.

The bio-informatics comparison of the bacterial genes present in the UC patients and healthy controls has begun and the first results indicate that some bacterial species differ in the two groups. If fully confirmed, this may well lead to a break-through in our understanding of this disease.

Obesity is associated with a number of co-morbidities, such as diabetes, hypertension and cardiovascular diseases. These co-morbidities are found typically in individuals with visceral rather than general. We planned to compare 60 individuals of each type with 60 lean individuals. As in the UC study, the clinical part has been completed. The individuals from a large cohort, Inter99, established in 1999 in Denmark, were enrolled in our study. They were examined at the entry in the study and the observation collected can be compared with those obtained 5 and 9 years ago for all of them. Their stool and blood samples were collected and examined. Once again, the first bio-informatics analyses point to the differences in bacterial species between the obese and lean individuals, that could lead to a breakthrough in the comprehension of this ever-increasing disease.